ovarian carcinomas การใช้

• Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.
• Gain of EMT markers was found to be associated with the resistance of ovarian carcinoma epithelial cell lines to paclitaxel.
• Supporting this is the observation that in ovarian carcinomas, loss of c-Fos expression correlates with disease progression.
• DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines.
• The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors.
• When studied in Cp70 ovarian carcinoma cells, hypermethylation of a CpG island immediately upstream of the YPEL3 promoter has been seen to down regulate YPEL3 expression.
• The study suggest that an epigenetically mediated immune response is a predictor of recurrence and, possibly, treatment response for high-grade serous epithelial ovarian carcinomas.
• It was identified because it reacts with the monoclonal antibody K1 in cells, such as the ovarian carcinoma line OVCAR-3, also expressing the CAKI surface glycoprotein.
• Endocervical . brush sampling at time of pap smear to detect adenocarcinoma and its precursors is necessary along with a patient / Dr . vigilance on abdominal symptoms associated with uterine and ovarian carcinoma.
• ZNF541 and PNMAL2, in relation to TMEM143, have been documented as having a role in the allelic loss of q13.3 of chromosome 19 . This loss results in documented cases of malignant gliomas, neuroblastomas, and ovarian carcinomas, all suggesting a tumor suppression gene or genes in this region.
• A specific tumour protein 53 ( " TP53 ) " expression pattern in the Fallopian tube epithelium  the  p53 signature-is thought to be a precursor marker of HGSC . TP53-/-mice ( in which the TP53 gene has been deleted ) do not develop ovarian carcinomas.
• These proteins have three highly positively charged regions, termed AT hooks, that bind the minor groove of AT-rich DNA stretches in specific regions of DNA . Human neoplasias, including thyroid, prostatic, cervical, colorectal, pancreatic and ovarian carcinomas, show a strong increase of HMGA1a and HMGA1b proteins.
• These proteins have three highly positively charged regions, termed AT hooks, that bind the minor groove of AT-rich DNA stretches in specific regions of DNA . Human neoplasias, including thyroid, prostatic, cervical, colorectal, pancreatic and ovarian carcinoma, show a strong increase of HMGA1a and HMGA1b proteins.
• With regards to oncology, PSMB9 in conjunction with other genes that are involved with immune response processes ( TAP1, PSMB8, PSMB9, HLA-DQB1, HLA-DQB2, HLA-DMA, and HLA-DOA ) may form a comprehensive assessment of the clinical outcome in epithelial ovarian carcinoma tumor methylation assessments.
• The most promising result was achieved in patients with stage 2 and 3 of ovarian carcinoma . The " in vitro " study of IFN-gamma in cancer cells is more extensive and results indicate anti-proliferative activity of IFN-gamma leading to the growth inhibition or cell death, generally induced by apoptosis but sometimes by autophagy.
• Notably, GJA1 expression has been associated with a wide variety of cancers, including nasopharyngeal carcinoma, meningioma, hemangiopericytoma, liver tumor, colon cancer, esophageal cancer, breast cancer, mesothelioma, glioblastoma, lung cancer, adrenocortical tumors, renal cell cancer, cervical carcinoma, ovarian carcinoma, endometrial carcinoma, prostate cancer, thyroid carcinoma, and testis cancer.
• Preclinical and clinical work suggests multiple potential mechanisms of drug resistance in " ROS1 " + lung cancer, including kinase domain mutations in " ROS1 " and bypass signaling via EGFR . Although the most preclinical and clinical studies of " ROS1 " gene fusions have been performed in lung cancer, " ROS1 " fusions have been detected in multiple other tumor histologies, including ovarian carcinoma, sarcoma, cholangiocarcinomas and others.